Foscarnet salvage therapy for acyclovir-resistant varicella zoster: report of a novel thymidine kinase mutation and review of the literature.

نویسندگان

  • Todd Hatchette
  • Graham A Tipples
  • Geoff Peters
  • Ahmed Alsuwaidi
  • Jianwei Zhou
  • Timothy Lloyd Mailman
چکیده

The authors describe an acyclovir-resistant varicella zoster virus infection in a pediatric patient after hematopoietic stem cell transplant, the use of foscarnet as salvage therapy, and review the literature to clarify the pediatric experience with foscarnet in this setting. A novel thymidine kinase mutation is described, along with a new phenotypic assay for characterizing acyclovir resistance in varicella zoster virus.

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عنوان ژورنال:
  • The Pediatric infectious disease journal

دوره 27 1  شماره 

صفحات  -

تاریخ انتشار 2008